The Jaguars are looking to bounce back after a tough loss to the Bills in their 2013 home finale against the division rival Titans.
The two teams have gone in different directions since the Titans gave the Jaguars their first win of the season back in November. Since then, the Jaguars have won three of five while the Titans have dropped four of their last five.
Despite both teams recent record, the Titans are five point favorites on the road.
The Jaguars could be without running back Maurice Jones-Drew (hamstring) which could mean another big day for backup Jordan Todman against a Titans defense that is allowing 119 yards per game on the ground.
Game time: 1:00 p.m. ET
Location: EverBank Field, Jacksonville, FL
Announcers: Andrew Catalon, Adam Archuleta
Radio: WOKV 690/104.5 (Click listen live), Sirius XM
Odds: The Titans are 5 point road favorites
Last time they played: Jaguars won, 29-27 (2013)
Series History: 21-17 in favor of the Titans