A strong opening drive for the Jaguars was stopped when a double reverse to Cecil Shorts was stopped for a five yard loss and a Robert Mathis sack/forced fumble that was recovered by Guy Whimper ended the drive. The Jaguars instead settled for a 44-yard field goal from Josh Scobee to take a 3-0 lead.
When a pass interference call on Rashean Mathis nullified a would-be interception, the Colts took advantage with a 40-yard touchdown pass from Luck to T.Y. Hilton to grab the lead.
The Jaguars continued to run the ball well, but Gabbert completed 6-of-11 passes for 48 yards and was largely ineffective, stunting the ensuing drives. Meanwhile, a late second quarter drive orchestrated by Luck ended in a Mewelde Moore touchdown reception to give the Colts a 14-3 lead.