There are certainly some questions for the Jaguars, especially on the offensive side of the ball. How will Toby Gerhart play in his first feature role? Will rookie receivers Marqise Lee, Allen Robinson, and Allen Hurns elevate their game for the regular season? Can Chad Henne stave off Blake Bortles as the starting quarterback?
Here's everything you need to know to watch, listen to, and follow the game online:
Game time: Sunday, September 7, 1 p.m. (Jacksonville time)
Location: Lincoln Financial Field, Philadelphia, Pennsylvania
TV channel: CBS
Radio: 1010XL AM or 92.5 FM | Full listings
Online streaming: Verizon subscribers can watch games live with the NFL Mobile app (subscription required) | NFL Game Pass offers live online broadcasts to users outside the USA.
Announcers: Andrew Catalon, Steve Beuerlein, and Steve Tasker
Odds: Eagles are 10.5-point favorites
Jaguars injury report: OUT: Austin Pazstor, Clay Harbor, and Storm Johnson / QUESTIONABLE: Cecil Shorts III and Josh Wells / PROBABLE: Zane Beadles, Josh Scobee, Sen'Derrick Marks, Allen Robinson, Bryan Anger, and Luke Bowanko
Prediction: Jaguars lose 37-20
Matchup history: The Jaguars lead 3-1
Fun fact: Except for the Tampa Bay Buccaneers, the Philadelphia Eagles have the worst winning percentage against the Jaguars.
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