The Colts finished with a 4-12-1 record last year, including 1-1 against the Jags, after four straight seasons with 7+ wins under Frank Reich.
Indy will be debuting either former Jacksonville cult hero Gardner Minshew or fourth overall draft pick Anthony Richardson. Regardless of who starts at quarterback for first-year coach Shane Steichen, the Colts have a lot of new faces, which should benefit the Jaguars.
Jacksonville is listed as 3.5-point favorites at DraftKings Sportsbook for Week 1.
Here’s a full look at Jacksonville’s 2023 regular season schedule: